The authors assessed outcomes of left atrial appendage (LAA) ligation with the Lariat device in 139 patients with nonvalvular atrial fibrillation (AF) ineligible for oral anticoagulation. Acute closure was achieved in 99% of patients, and 90% had complete closure at day 30 to 45. There was a periprocedural adverse event rate of 11.5%, including 1 death. The rate of a composite of stroke and systemic embolism was 1.0% per year, and the rate of a composite of stroke, embolism, and all-cause mortality was 2.8% per year over the mean follow-up period of 2.9 ± 1.1 years.
These findings suggest that LAA ligation with the Lariat device may be a beneficial option for patients with AF who cannot receive anticoagulation therapy, but additional studies will be needed.
JACCCEP. 2015;():. doi:10.1016/j.jacep.2015.08.005
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